Ratar

How to probe and validate a potential target remains one of the key questions in basic research in life sciences. In the DFG-project “Read-Across the Targetome” (Ratar), we will use binding site similarity to predict off-targets and to extrapolate compound information from one target to another. This similarity-based knowledge transfer can suggest tool compounds (chemical probes) and off-targets for proteins of interest using the ever-growing amount of available target and compound data.

Read-across the targetome (Ratar) aims to support off-target or polypharmacology studies for a query target using (structural) binding site comparison. Known binders of the most similar binding sites are proposed as tool compounds for the query target.

Figure: Read-across the targetome (Ratar) aims to support off-target or polypharmacology studies for a query target using (structural) binding site comparison. Known binders of the most similar binding sites are proposed as tool compounds for the query target.

Software and resources

  • ratar · Binding site comparison tool (WIP)

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Funding

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